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Output Category: C1: Review Article in Journal
Strategic Research Area: None
TISI Citations: 23 PlumX StatisticsPlumX Statistics
Scopus Citations: 8
Journal Impact: 10.16
All Authors: Knott, G, Bond, C, Fox, A Number: 3
UWA Authors: Knott, G., Bond, C., Fox, A. Number: 2
Title: The DBHS proteins SFPQ, NONO and PSPC1: A multipurpose molecular scaffold
Journal: Nucleic Acids Research   
ISBN/ISSN 0305-1048
Year: 2016
Pages: 3989-4004
Volume: 44
Issue: 9
Full Reference (Harvard Style): Knott, G., Bond, C., Fox, A. 2016, 'The DBHS proteins SFPQ, NONO and PSPC1: A multipurpose molecular scaffold', Nucleic Acids Research, 44, 9, pp. 3989-4004.
© 2016 The Author(s).Nuclear proteins are often given a concise title that captures their function, such as 'transcription factor,' 'polymerase' or 'nuclear-receptor.' However, for members of the Drosophila behavior/human splicing (DBHS) protein family, no such clean-cut title exists. DBHS proteins are frequently identified engaging in almost every step of gene regulation, including but not limited to, transcriptional regulation, RNA processing and transport, and DNA repair. Herein, we present a coherent picture of DBHS proteins, integrating recent structural insights on dimerization, nucleic acid binding modalities and oligomerization propensity with biological function. The emerging paradigm describes a family of dynamic proteins mediating a wide range of protein-protein and protein-nucleic acid interactions, on the whole acting as a multipurpose molecular scaffold. Overall, significant steps toward appreciating the role of DBHS proteins have been made, but we are only beginning to understand the complexity and broader importance of this family in cellular biology.